Siren,

$4.9B 13F equity value
124 Holdings
Quarter ended June 30, 2026

The latest 13F on file for Siren, covers the quarter ended June 30, 2026. Institutional managers report holdings quarterly to the SEC, so each filing is a snapshot of positions held on that date.

Top Holdings

TickerCompanySharesValueWeight
SRRKScholar Rock Holding Corp9,575,013$527M10.7%
KYMRKymera Therapeutics Inc2,935,830$337M6.8%
ERASErasca Inc11,397,781$209M4.2%
MANEVeradermics Inc1,655,374$204M4.1%
TNGXTango Therapeutics Inc6,179,364$193M3.9%
RVMDRevolution Medicines Inc900,000$169M3.4%
BCAXBicara Therapeutics Inc5,602,970$166M3.4%
ARWRArrowhead Pharmaceuticals Inc1,715,476$140M2.8%
ONCBeOne Medicines AG465,000$133M2.7%
EWTXEdgewise Therapeutics Inc3,184,629$129M2.6%

Track Siren,'s 13F portfolio: $4.9B in reported holdings, 124 positions. Top holdings and quarterly changes on SentiSense.

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