Karyopharm Therapeutics Inc. (KPTI)
PHARMACEUTICAL PREPARATIONS
Karyopharm Therapeutics Inc. (KPTI) is listed on Nasdaq, where it has traded since November 6, 2013.
- Listed On
- Nasdaq
- Listed Since
- November 6, 2013
- Employees
- 228
- Market Cap
- $37M
About Karyopharm Therapeutics Inc.
Karyopharm Therapeutics Inc is a commercial-stage pharmaceutical company focused on novel cancer therapies and dedicated to the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company conducts research focused on intracellular communication between the nucleus and cytoplasm and has developed small-molecule compounds that inhibit exportin 1 (XPO1), a nuclear export protein. It is focused on marketing XPOVIO (selinexor).
Institutional ownership
In 13F filings for the quarter ended June 30, 2026, 93 institutions reported holding KPTI, with 21.2 million shares worth $206.8 million in aggregate. The largest reported holder was RA Capital Management,, with 1.9 million shares worth $18.7 million. Of the 5 largest holders listed below, 3 added shares, 1 reduced its position and 1 held its position unchanged during the quarter.
| Institution | Shares | Value | Quarter change |
|---|---|---|---|
| RA Capital Management, | 1,917,354 | $19M | Unchanged |
| Adage Capital Partners GP, | 1,521,322 | $15M | Reduced 15.78% |
| Acorn Capital Advisors | 1,518,113 | $15M | Added 427.44% |
| Goldman Sachs | 1,424,658 | $14M | Added 50.35% |
| BlackRock | 1,418,799 | $14M | Added 479.34% |
Form 13F is a quarterly report that institutional investment managers with at least $100 million in qualifying securities file with the SEC. It lists long positions as of the last day of the quarter and is due within 45 days of quarter end, so these holdings describe that date rather than today.
Frequently asked questions
What is KPTI?
Karyopharm Therapeutics Inc. (KPTI) is listed on Nasdaq, where it has traded since November 6, 2013.
Who are the largest institutional holders of KPTI?
In 13F filings for the quarter ended June 30, 2026, the largest reported holders of KPTI were RA Capital Management,, Adage Capital Partners GP, and Acorn Capital Advisors.
How many institutions own KPTI?
93 institutions reported a position in KPTI for the quarter ended June 30, 2026, worth $206.8 million in total.
Did institutions buy or sell KPTI last quarter?
Of the 5 largest reported holders, 3 added shares, 1 reduced its position and 1 held its position unchanged during the quarter. Every reported holder and its change is on the SentiSense ownership page for KPTI.
Every reported institutional holder, plus insider and congressional trades in KPTI, on SentiSense.