Spyre Therapeutics, Inc. Common Stock (SYRE) Ownership & Trading Activity
Institutional holders, insider transactions, and congressional trades for SYRE. 13F holdings as of 2026-06-30.
In 13F filings for the quarter ended June 30, 2026, 258 institutions reported holding SYRE, with 95.8 million shares worth $8.5 billion in aggregate.
Top Institutional Holders
| Institution | Shares | Value | Change |
|---|---|---|---|
| FMR | 13,026,187 | $1.2B | INCREASED |
| BlackRock | 6,506,605 | $578M | INCREASED |
| Vanguard | 6,423,758 | $570M | INCREASED |
| Perceptive Advisors | 4,319,496 | $383M | INCREASED |
| Rtw Investments | 4,251,996 | $377M | INCREASED |
Recent Insider Trades
| Insider | Type | Shares | Value | Date |
|---|---|---|---|---|
| Heidy King-Jones (Chief Legal Officer and Corporate Secretary) | EXERCISE | 28,933 | $420K | 2026-10-01 |
| Heidy King-Jones (Chief Legal Officer and Corporate Secretary) | SELL | 2,600 | $243K | 2026-10-01 |
| Heidy King-Jones (Chief Legal Officer and Corporate Secretary) | SELL | 2,100 | $195K | 2026-10-01 |
| Heidy King-Jones (Chief Legal Officer and Corporate Secretary) | SELL | 7,228 | $660K | 2026-10-01 |
| Heidy King-Jones (Chief Legal Officer and Corporate Secretary) | SELL | 16,605 | $2M | 2026-10-01 |
Full institutional holdings, insider history, and congressional trades for Spyre Therapeutics, Inc. Common Stock on SentiSense.