Spyre Therapeutics, Inc. Common Stock (SYRE) Ownership & Trading Activity
Institutional holders, insider transactions, and congressional trades for SYRE. 13F holdings as of 2026-03-31.
Top Institutional Holders
| Institution | Shares | Value | Change |
|---|---|---|---|
| FMR LLC | 11,781,024 | $594M | INCREASED |
| BlackRock, Inc. | 5,521,221 | $278M | DECREASED |
| RTW INVESTMENTS, LP | 4,171,996 | $210M | UNCHANGED |
| Fairmount Funds Management LLC | 4,018,101 | $203M | UNCHANGED |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | $191M | INCREASED |
Recent Insider Trades
| Insider | Type | Shares | Value | Date |
|---|---|---|---|---|
| Fairmount Funds Management LLC (Director) | OTHER | 666,680 | 2026-06-23 | |
| Fairmount Funds Management LLC (Director) | SELL | 4,684,781 | $400M | 2026-06-23 |
| Michael Thomas Henderson (Director) | SELL | 20,000 | $2M | 2026-06-22 |
| Sheldon Sloan (Chief Medical Officer) | EXERCISE | 8,333 | $229K | 2026-06-03 |
| Sheldon Sloan (Chief Medical Officer) | SELL | 8,333 | $625K | 2026-06-03 |
Full institutional holdings, insider history, and congressional trades for Spyre Therapeutics, Inc. Common Stock on SentiSense.