Spyre Therapeutics, Inc. Common Stock (SYRE) Ownership & Trading Activity

Institutional holders, insider transactions, and congressional trades for SYRE. 13F holdings as of 2026-06-30.

Top Institutional Holders

InstitutionSharesValueChange
FMR13,026,187$1.2BINCREASED
BlackRock6,506,605$578MINCREASED
Vanguard6,423,758$570MINCREASED
Perceptive Advisors4,319,496$383MINCREASED
Rtw Investments4,251,996$377MINCREASED

Recent Insider Trades

InsiderTypeSharesValueDate
Cameron Turtle (Chief Executive Officer)SELL400$36K2026-09-01
Cameron Turtle (Chief Executive Officer)SELL3,700$326K2026-09-01
Cameron Turtle (Chief Executive Officer)SELL8,400$732K2026-09-01
Cameron Turtle (Chief Executive Officer)SELL2,500$216K2026-09-01
Scott L Burrows (Chief Financial Officer)EXERCISE7,500$109K2026-09-01

Full institutional holdings, insider history, and congressional trades for Spyre Therapeutics, Inc. Common Stock on SentiSense.