SPDR S&P Biotech ETF (XBI)
Equity ETF ยท SPDR
SPDR S&P Biotech ETF (XBI) is an exchange traded fund from SPDR that tracks the S&P Biotechnology Select Industry Index. The fund holds $10.08 billion in assets and charges an expense ratio of 0.35%. It launched on 2006-01-31. Its composition runs to 159 positions, the ten largest of which are listed below, as of 2026-10-01. SentiSense classifies it as an equity fund and tracks news coverage and holdings weighted sentiment for it. Full holdings, flows and per holding sentiment for XBI are on the SentiSense fund page.
- Issuer
- SPDR
- Tracks
- S&P Biotechnology Select Industry Index
- Asset Class
- Equity
- Assets
- $10.1B
- Expense Ratio
- 0.35%
- Inception
- 2006-01-31
- Listed On
- NYSE Arca
- Holdings
- 159
Ten largest holdings
| Holding | Symbol | Weight |
|---|---|---|
| TWIST BIOSCIENCE CORP | TWST | 2.2% |
| MODERNA INC | MRNA | 2.04% |
| NATERA INC | NTRA | 1.81% |
| UNITED THERAPEUTICS CORP | UTHR | 1.65% |
| IOVANCE BIOTHERAPEUTICS INC | IOVA | 1.59% |
| BIOGEN INC | BIIB | 1.55% |
| AMGEN INC | AMGN | 1.53% |
| ABBVIE INC | ABBV | 1.52% |
| SPYRE THERAPEUTICS INC | SYRE | 1.52% |
| CRISPR THERAPEUTICS AG | CRSP | 1.49% |
Showing the ten largest of 159 positions, as of 2026-10-01.
Frequently asked questions
What does XBI track?
SPDR S&P Biotech ETF tracks the S&P Biotechnology Select Industry Index. It is issued by SPDR.
What is XBI's expense ratio?
SPDR S&P Biotech ETF charges an expense ratio of 0.35%, which is the annual cost of holding the fund as a share of assets.
How big is XBI?
SPDR S&P Biotech ETF holds $10.08 billion in assets under management, spread across 159 positions.
What are XBI's largest holdings?
The largest positions in SPDR S&P Biotech ETF are TWIST BIOSCIENCE CORP, MODERNA INC and NATERA INC. Composition is as of 2026-10-01. The ten largest are listed on this page and the full composition is on the SentiSense fund page.
Full holdings, fund flows and holdings weighted sentiment for SPDR S&P Biotech ETF on SentiSense.